Matthew Wyatt Kay, PE, DSc

Research

Dr. Kay’s research focus is to understand the dynamics of cardiac electrical activity during normal and disease conditions. He is currently studying alterations in electrical activity during ischemia and reperfusion using fluorescence imaging. Coronary occlusions are the cause of ischemia and reperfusion events, which may then disrupt normal electrical activity and create electrical rotors. The mechanism of many deadly arrhythmias is electrical rotors but rotor formation remains to be fully understood. Dr. Kay’s team has perfected methods to recreate coronary occlusions and study electrical activity in the laboratory using fully functioning explanted animal hearts. A goal is to determine how occlusion-induced alterations in metabolism, electrical conduction, and intracellular calcium cycling create rotors. These studies are advantageous for testing new clinical device prototypes and pharmaceutical therapies for preventing the formation of electrical rotors during a coronary occlusion.